Breakthrough in Metastatic Cancer Treatment: Promising Results from TransCode Therapeutics' TTX-MC138

Exciting New Data from TransCode Therapeutics

TransCode Therapeutics, an innovative biotechnology company dedicated to using RNA therapeutics to fight cancer, has unveiled promising data from its first-in-human clinical study. The focus of this study is their leading therapeutic candidate, TTX-MC138, designed to treat metastatic cancer.

In the preliminary Phase 0 clinical trial, the main target was a molecule called miRNA-10b, often found in high amounts in metastatic tumors. The results are encouraging, showing that even a tiny dose of radiolabeled TTX-MC138 can substantially cut down the levels of miRNA-10b in the blood of cancer patients.

Study Highlights: Significant Target Inhibition

After administering a microdose of radiolabeled TTX-MC138, researchers observed a remarkable 66% reduction in the levels of miRNA-10b within just 24 hours. TTX-MC138 effectively targets this molecule, which is crucial for the growth and spread of various cancers.

Zdravka Medarova, PhD, Chief Scientific Officer at TransCode, highlighted that similar results in animal studies led to complete regression of metastatic tumors. This is highly significant as it demonstrates the therapeutic potential of TTX-MC138 in human patients, offering new hope for those with metastatic cancer.

Effective Delivery to Metastatic Tumors

Another vital component of the study was measuring the delivery efficiency of TTX-MC138 to metastatic tumors. The data shows that the drug candidate accumulates effectively in cancerous lesions, confirming its targeted delivery mechanism.

Dr. Daniel Vlock, Chief Medical Officer at TransCode, stressed that these results support the potential use of TTX-MC138 in a broader range of metastatic cancers. The ability to inhibit miRNA-10b at a single microdose indicates a potentially extended therapeutic window, which is a critical factor in cancer treatment.

Optimistic Outlook for Future Studies

The current study also reported that the microdose of TTX-MC138 was well tolerated by the patient with no adverse effects, paving the way for continued clinical development.

The study's full analysis is still ongoing, but these preliminary results are a promising start. The next steps involve more extensive Phase 1 clinical trials to verify these findings and further explore the therapeutic capabilities of TTX-MC138 in fighting metastatic cancers.

About TransCode Therapeutics

TransCode Therapeutics is a forward-thinking biotechnology company specializing in RNA-based treatments for cancer. Their pioneering approach aims to defeat metastatic disease through advanced RNA research and targeted therapeutic delivery systems.

Their primary therapeutic candidate, TTX-MC138, stands out for targeting microRNA-10b, a biomarker strongly associated with metastasis. Their ongoing research includes multiple RNA-based drug candidates expected to unlock new genetic targets and transform cancer treatment paradigms.

Forward-Looking Statements and Future Plans

The potential for TTX-MC138 is vast, but the journey from promising data to widely-available treatment involves rigorous clinical trials and regulatory hurdles. TransCode is committed to advancing their clinical studies to bring effective, RNA-based cancer treatments to patients worldwide.

Breakthrough in Metastatic Cancer Treatment: Promising Results from TransCode Therapeutics' TTX-MC138

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