New ProteXidine Molecule: A Breakthrough in UV Protection

The Problem with UV Radiation

Exposure to the sun's ultraviolet (UV) rays is one of the main causes of skin aging. About 90% of visible skin aging is due to sun damage, even if you regularly use sunscreen. UV rays generate Reactive Oxygen Species (ROS), a type of free radical, leading to premature aging, wrinkles, and even skin cancer.

Understanding the harmful effects of UV radiation on the skin is crucial. These rays penetrate deep into the skin layers and generate free radicals, which in turn damage the cells and DNA. This damage shows up as sagging skin, hyperpigmentation, and more severe conditions like skin cancer.

Introducing ProteXidine

TOPIX Pharmaceuticals has partnered with the University of Minnesota's Center for Drug Design to create a new molecule called ProteXidine, which aims to combat UV-induced skin damage. This molecule mimics natural skin processes and helps the skin manage UV-caused damage more efficiently.

ProteXidine works by preventing the formation of harmful molecules called Cyclobutane Pyrimidine Dimers (CPDs) in the DNA, which are indicators of UV damage. Additionally, it helps enhance the skin’s natural repair process, reducing the effects of these dimers and promoting healthier skin cells.

Backed by Scientific Research

The development of ProteXidine is the result of almost a decade of research. Clinical trials show that ProteXidine can significantly reduce the signs of UV damage in the skin. It was observed that skin treated with ProteXidine demonstrated a marked reduction in CPDs, even after UV exposure, compared to untreated skin.

Clinical evidence suggests that ProteXidine can lead to nearly complete clearance of CPDs within 12 hours of application. In untreated skin, however, CPDs remained high, showing the clear efficacy of this innovative treatment.

Benefits of ProteXidine

ProteXidine not only prevents and repairs UV damage but also helps maintain the skin’s collagen structure. Collagen is vital for keeping skin firm and youthful. ProteXidine's role in preserving collagen density ensures that the skin retains its structural integrity, preventing sagging and premature aging.

Additionally, ProteXidine aids in the removal of damaged epidermal cells, which are replaced with fresh, healthy cells. This turnover ensures that skin remains vibrant and healthy-looking, even after sun exposure.

Industry Impact

Brenda Wu, President & CEO of TOPIX Pharmaceuticals, emphasizes the significance of ProteXidine: “With ProteXidine, we are bringing a revolutionary product to our partners and their patients. It offers a more advanced level of protection against UV damage, a universal issue we all face.”

Board-certified dermatologist Dr. Naiem Issa also shares his excitement: “ProteXidine is changing the way we approach skincare. It can become a staple in daily skin routines, similar to sunscreen, providing long-lasting protection and repair.”

About TOPIX Pharmaceuticals and the University of Minnesota

TOPIX Pharmaceuticals has been a leader in professional skincare solutions for over 40 years. The company is dedicated to providing dermatologists, plastic surgeons, and med spas with innovative, safe, and effective skincare products.

The University of Minnesota’s Center for Drug Design, founded by Prof. Robert Vince, focuses on developing new therapeutic drugs. Their research spans various medical fields, contributing significantly to advancements in drug design and dermatological treatments.